Menopause International > Volume 15, Number 3 > Pp. 134-138

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Reviews

Hormone replacement therapy and the endometrium

S Daayana and C M Holland 

Academic Unit of Obstetrics and Gynaecology, University of Manchester School of Cancer and Imaging Science, St Mary's Hospital, Manchester, UK

Correspondence: C M Holland, Academic Unit of Obstetrics and Gynaecology, University of Manchester School of Cancer and Imaging Science, St Mary's Hospital, Whitworth Park, Manchester M13 0JH, UK. Email: Cathrine.holland{at}manchester.ac.uk
The life-expectancy for women has increased significantly in the 20th century, although the time of onset of menopause has not. Almost a third of a woman's life is now postmenopausal and therefore many postmenopausal women consider using hormone replacement therapy (HRT) to improve their quality of life. Most cases of endometrial carcinoma arise in postmenopausal women and this raises concern among patients and clinicians with regard to the safety of HRT in this age group. Whenever the use of HRT is considered, a careful consideration of the actual benefit in terms of symptom relief and quality of life must be balanced against the risks for each individual woman. This review discusses the effects of HRT on the endometrium and the evidence regarding HRT use and risk of endometrial cancer.

Key Words: HRT • unscheduled bleeding • endometrial carcinoma

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